Darkest Dungeon 2 How To Make An Overpowered Plague Doctor

Darkest Dungeon 2: How To Make An Overpowered Plague Doctor

The Plague Doctor is a great backline healer and Blighter. If you’re unsure what Trinkets she should use or which abilities are best, we’ve got you.



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Darkest Dungeon 2 How To Make An Overpowered Plague Doctor

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Of all of the party members you can take along with you on your journey to the mountain in Darkest Dungeon 2, the Plague Doctor is one of the most valuable – especially for newer players. She can heal, inflict some powerful status effects, and is a fantastic backliner.

The early game is the roughest part of Darkest Dungeon 2 as you won’t have many resources and the majority of your party’s skills will remain un-upgraded, but once you get the ball rolling the Plague Doctor can easily be one of the greatest assets you have.

This guide was written during the Early Access release of Darkest Dungeon 2. These details are subject to changes as a result.

Plague Doctor Abilities

Darkest Dungeon 2 How To Make An Overpowered Plague Doctor

The Plague Doctor’s abilities largely revolve around healing her allies and inflicting status effects on the enemies. She’s great with Blight, but can also inflict Bleed, Blindness, and Burn. The table below details all of the Plague Doctor’s abilities.

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Some of these abilities are unlocked by visiting Shrines of Reflection.

  • Emboldening Vapors is gained on the first visit.
  • Plague Grenade is gained on the second visit and after beating the battle therein.
  • Indiscriminate Science is gained on the third visit.
  • Cause of Death is gained on the fourth visit and beating the battle therein.
  • Disorienting Blast and Magnesium Rain are gained on the fifth visit.

Which skills you use will largely depend on your party makeup but there are some standouts. Noxious Blast and Plague Grenade are two of the Plague Doctor’s most potent abilities and enable her to stack quite a lot of Blight amongst the enemy party. She can also support allies who use Bleed and Burn with her own status-inflicting abilities.



If your party uses a lot of Burn, Blight, or Bleed it would be a great idea to get Cause of Death – you can reach frighteningly huge damage numbers with enough stacks of these status effects.

Ounce of Prevention is a really fantastic ability, especially when upgraded at the Mastery Trainer. Having more resistance against nasty ailments is brilliant, but the Stress healing aspect of the move cannot be ignored as Stress is probably the main cause of failure in Darkest Dungeon 2.

Battlefield Medicine is a must-have for pretty much any party setup. It’s not entirely necessary to upgrade it for the higher healing, but it’s fantastic for relieving the pressure of DoT effects and getting rid of Death’s Door.

Plague Doctor Shrine Battles

Darkest Dungeon 2 How To Make An Overpowered Plague Doctor

The Plague Doctor has two Shrine of Reflection battles that she must face alone to unlock some skills.

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Second Shrine Visit: Head Of The Class

This battle sets the Plague Doctor up against a Professor. She will have two moves available, Review Notes and Heated Rebuttal. Only use Review Notes to begin with, waiting until the Professor uses Conclusion. This is when you should use Heated Rebuttal. After this, wait for the Professor to use Conclusion again.


If you use Heated Rebuttal before the Professor uses Conclusion you will take Stress damage and end up losing the fight.

Once you successfully use Heated Rebuttal twice, you should win.

Fourth Shrine Visit: Failing Grade

This battle is also against the Plague Doctor’s Professor, only this time as a reanimated corpse. This battle proceeds in a rather standardized way – use Stitch to try and save the Professor from his Bleed damage and then put him out of his misery with Stab once the option comes up.

Plague Doctor Tips

While every run is different, there are some things to keep in mind when using the Plague Doctor.

  • She excels when used in the back ranks of the party. Try to keep her there as much as possible and consider equipping her with Trinkets that increase her Move resistance if you come across any.
  • When paired up with close-range attackers like the Man-At-Arms or the Leper, Magnesium Rain is a must-have for clearing corpses and allowing them to do their job.
  • Pair her with the Runaway to really stack the Burns onto enemies.
  • If you like stacking lots of Blight, try pairing her with someone who can easily Mark enemies – such as the Highwayman with an upgraded Tracking Shot. This will make enemy resistances much less of a problem when using Noxious Blast, her best Blight ability.
  • Trinkets that increase speed are good for ensuring the Plague Doctor gets her turns early in a round. This can be good for shoring up the HP of a weakened ally or staving off Death’s Door.
  • Don’t bother fishing for outright kills or critical hits with the Plague Doctor’s Trinkets, most of her usefulness comes from passive damage and buffing the party.
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